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陈铭 博士
教授
厦门大学，海洋与地球学院，海洋生物科学与技术系；厦门大学海洋生物制备技术国家地方联合工程实验室 |
Ming Chen
Professor
Department of Marine Biological Science & Technology, College of Ocean & Earth Sciences, Xiamen University. State-Province Joint Engineering Laboratory of Marine Bioproducts and Technology, Xiamen University |
Tel: 0592-2880818
Email: ming.chen@xmu.edu.cn
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个人简介 |
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个人履历
Brief CV |
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1998年9月—2002年7月：
北京大学，药学院， 药学学士
B.Sc. in Pharmaceutical sciences, Peking University, China
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2002年8月-2003年8月:
瑞士Basilea Pharmaceutical AG中国，实验室研究员
Basilea Pharmaceutical AG，China，Researcher
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2004年9月—2007年7月：
北京大学，药学院，药剂学硕士
M.Sc. in Pharmaceutics, Peking University, China
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2007年9月—2011年5月：
德国耶拿大学，药剂系，药剂学博士
Ph.D. in Pharmaceutics, Friedrich-Schiller-Universität Jena, Germany
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2011年8月—2014年6月:
美国加州大学圣芭芭拉分校，化学/生物工程中心，博士后
Post-Doc, University of California, Santa Barbara, USA
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2015年4月---2021年12月： 厦门大学，海洋与地球学院，副教授 Associate Professor, Xiamen University, China
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2022年1月---至今： 厦门大学，海洋与地球学院，教授 Professor, Xiamen University, China
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研究方向
Research Interests |
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1.海洋生物医学材料 Marine Biomedical Materials
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2.经皮给药技术 Skin Drug Delivery
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3.海洋生物制药 Marine biopharmaceutic
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代表性论文
Selected Publications |
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1. XueJiao Liang, Jialiang Zhang, HuiLong Ou, Jun，Samir Mitragotri, Ming Chen*.Skin delivery of siRNA using sponge spicules in combination with cationic flexible liposomes. Molecular Therapy - Nucleic Acid. 2020. In press. doi.org/10.1016/j.omtn.2020.04.003
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2. Keda Zhang, Li Yu, Fu-Rong Li, Xue Li, Zhefeng Wang, Xiaoting Zou, Chi Zhang, Kongpeng Lv, Boping Zhou, Samir Mitragotri and Ming Chen*.Topical Application of Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells in Combination with Sponge Spicules for Treatment of Photoaging. International Journal of Nanomedicine. 2020:15,1-14.
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3. XueKe Lin, ZhenHua Wang, Huilong Ou, Samir Mitragotri, Ming Chen*. Correlations between skin barrier integrity and delivery of hydrophilic molecules in the presence of penetration enhancers, Pharmaceutical Research. 2020. doi.org/10.1007/s11095-020-02800-4
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4. Keda Zhang, Wanyang Sun, Alfred Fahr, Xiaobin Zeng,Lanlan Ge, Ming Chen*,Lingzhi Yang, Shipin Wu, Jia Fei and Boping Zhou. Skin-permeating components of Lonicera japonica flos: a comprehensive study from observations and model computations. New J. Chem., 2019, 43, 12538
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5. Chi Zhang, Keda Zhang, Jialiang Zhang, Huilong Ou, Jiwen Duan, Saiman Zhang, Dexiang Wang, Samir Mitragotri, Ming Chen*.Skin delivery of hyaluronic acid by the combined use of sponge spicules and flexible liposomes. Biomater Sci. 2019 Mar 26;7(4):1299-1310
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6. Xiaobin Zeng, Zhefeng Wang, Xiangli Liu, Ming Chen*, Alfred Fahr and Keda Zhang.Predicting the skin-permeating components of externally-applied medicinal herbs: application of a newly constructed linear free-energy relationship equation for human skin permeation.New J. Chem., 2018, 42, 11930
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7. Saiman Zhang, Huilong Ou, Chunyun Liu, Yuan Zhang, Samir Mitragotri, Dexiang Wang, and Ming Chen*. Skin Delivery of Hydrophilic Biomacromolecules Using Marine Sponge Spicules. Mol. Pharmaceutics 2017, 14, 3188−3200.
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8. Ming Chen, Sunny Kumar, Aaron C. Anselmo, Vivek Gupta, Deborah H. Slee, John A. Muraski, Samir Mitragotri. Topical delivery of Cyclosporine A into the skin using SPACE-peptide. Journal of controlled release, 199 (2015) 190-197.
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9. Ming Chen, Sunny Kumar,Aaron A Anselmo, John A Muraski and Samir Mitragotri,Enhanced Dermal Retention of Topically Applied Steroids using SPACE Peptide. Drug Deliv Transl Res. 2015 May 5. [Epub ahead of print]
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10. Sunny Kumar, Ming Chen, Michael Zakrewsky, Stefano Menegatti, and John A Muraski, Samir Mitragotri. Mechanisms of Peptides as Skin Penetration Enhancers. Journal of controlled release, 199 (2015) 168–178.
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11. M. Chen, M. Zakrewsky, V. Gupta, A.C. Anselmo, D.H. Slee, J.A. Muraski, S. Mitragotri, Topical delivery of siRNA into skin using SPACE-peptide carriers, Journal of controlled release, 179C (2014) 33-41.
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12. M. Chen, V. Gupta, A.C. Anselmo, J.A. Muraski, S. Mitragotri, Topical delivery of hyaluronic acid into skin using SPACE-peptide carriers, Journal of Controlled Release, 173 (2014) 67-74.
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13. Anselmo, A.C., Modery-Pawlowski, C.L., Menegatti, S., Kumar, S., Vogus, D.R., Tian, L.L., Chen, M., Squires, T.M., Gupta, A.S., and Mitragotri, S., "Platelet-like Nanoparticles (PLNs): Engineering Shape, Flexibility and Surface Chemistry of Nanocarriers to Target Vascular Injuries", ACS Nano, Epub (2015).
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14. Zhang K, Chen M, Scriba GK, Abraham MH, Fahr A, Liu X.Human skin permeation of neutral species and ionic species: extended linear free-energy relationship analyses.J Pharm Sci. 2012 Jun;101(6):2034-44.
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15. Haag SF, Chen M, Peters D, Keck CM, Taskoparan B, Fahr A, Teutloff C, Bittl R,Lademann J, Schäfer-Korting M, Meinke MC. Nanostructured lipid carriers as nitroxide depot system measured by electron paramagnetic resonance spectroscopy.Int J Pharm. 2011 Dec 15;421(2):364-9. Epub 2011 Oct 6. PMID:22001533
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16. Haag SF, Fleige E, Chen M, Fahr A, Teutloff C, Bittl R, Lademann J, Schäfer-Korting M, Haag R, Meinke MC. Skin penetration enhancement of core-multishell nanotransporters and invasomes measured by electron paramagnetic resonance spectroscopy. Int J Pharm. 2011 Sep 15;416(1):223-8. Epub 2011 Jul 1.PMID: 21745556
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17. Yang K, Gitter B, Rüger R, Wieland GD, Chen M, Liu X, Albrecht V, Fahr A. Antimicrobial peptide-modified liposomes for bacteria targeted delivery of temoporfin in photodynamicantimicrobial chemotherapy. Photochem Photobiol Sci. 2011 Oct;10(10):1593-601. Epub 2011 Jul 20. PMID: 21773628
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18. Keda Zhang, Ming Chen, Gerhard Scriba, Micheal H. Abraham, Afred Fahr, Xiangli Liu. Linear Solvation Energy Relationship (LSER) Analysis of Retention Factors in Cerasome Electrokinetic Chromatography (EKC). Journal of pharmaceutical science, 2011, Mar 31. doi: 10.1002/jps.22549.
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19. Ming Chen, Xiangli Liu, Alfred Fahr. Skin penetration and deposition of Carboxyfluorescein and Temoporfin from different lipid vesicles: In vitro study with finite and infinite dosage application. International journal of Pharmaceutics, 2011, Vol.408, 223–234.
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20. S. F. Haag, M. Chen, B. Taskoparan, A. Fahr, R. Bittl, C. Teutloff, R. Wenzel, J. Lademann, M. Schäfer-Korting, M. C. Meinke. Stabilization of reactive nitroxides using invasomes to allow prolonged EPR measurements. Skin Pharmacology & Physiology, 2011;24(6):312-21. doi: 10.1159/000330235.
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专利
Patent |
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1. US2014/0227172 A1（已授权，美国）
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2. WO 2014/123543 A2&A3
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3. CN201710666564.2
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4. CN201880000113.8
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5. CN201610267935.5
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6. ZL201610267764.6（已授权，中国）
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7. CN201910958941.9
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8. CN201911347585.3
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9. CN201811175149.8
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10. CN201910641196.5
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11. CN201910619867.8
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12. PCT/CN2019/108876
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13. PCT/CN2019/096166
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14. PCT/CN2018/077288
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15. PCT/CN2017/081167
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16. PCT/CN2020/073345
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17. US 16/028,036（已授权，美国）
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18. CN201910019931.9
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19. CN202010087124.3
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个人履历
Brief CV |
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1998年9月—2002年7月：北京大学，药学院， 药学学士
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厦门大学，海洋与地球学院，副教授（2015—）
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美国加州大学圣芭芭拉分校，化学工程系，博士后（2011—2015）
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德国耶拿大学，药剂系，药剂学博士（2007—2011）
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北京大学，药学院，药剂学硕士（2004—2007）
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北京大学，药学院， 药学学士（1998—2002）
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Associate Professor, Xiamen University, China (2015-)
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Post-Doc, University of California, Santa Barbara, USA (2011-2015)
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Ph.D. in Pharmaceutics, University Jena, Germany (2007-2011)
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M.Sc. in Pharmaceutics, Peking University, China (2004-2007)
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B.Sc.in Pharmaceutical science, Peking University, China (1998-2002)
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研究方向
Research Interests |
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海洋生物材料 Marine bio-materials
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海洋化妆品 Marine cosmetics
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海洋生物制药 Marine bio-pharmaceutics
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代表性论文
Selected Publications |
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1. XueJiao Liang, Jialiang Zhang, HuiLong Ou, Jun，Samir Mitragotri, Ming Chen*.Skin delivery of siRNA using sponge spicules in combination with cationic flexible liposomes. Molecular Therapy - Nucleic Acid. 2020. In press. doi.org/10.1016/j.omtn.2020.04.003
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2. Ming Chen, Sunny Kumar ,Aaron A Anselmo, John A Muraski and Samir Mitragotri, Enhanced Dermal Retention of Topically Applied Steroids using SPACE Peptide. Drug Deliv Transl Res. 2015 May 5. [Epub ahead of print]
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3. Sunny Kumar, Ming Chen, Michael Zakrewsky, Stefano Menegatti, and John A Muraski, Samir Mitragotri. Mechanisms of Peptides as Skin Penetration Enhancers. Journal of controlled release, 199 (2015) 168–178.
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4. M. Chen, M. Zakrewsky, V. Gupta, A.C. Anselmo, D.H. Slee, J.A. Muraski, S. Mitragotri, Topical delivery of siRNA into skin using SPACE-peptide carriers, Journal of controlled release, 179C (2014) 33-41.
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5. M. Chen, V. Gupta, A.C. Anselmo, J.A. Muraski, S. Mitragotri, Topical delivery of hyaluronic acid into skin using SPACE-peptide carriers, Journal of Controlled Release, 173 (2014) 67-74
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