论文著作 Publications

Bai, Y.Q., Zhang, W.B., Zheng, W.B., Meng, X.Z., Duan, Y.Y., Zhang, C., Chen, F.Y.*, Ke-Jian Wang*, A 14-amino acid cationic peptide Bolespleenin334-347 from the marine fish mudskipper Boleophthalmus pectinirostris exhibiting potent antimicrobial activity and therapeutic potential, Biochemical Pharmacology, 226(2024)116344

Chen, R.S., Yan, J.J., Li, S., Ke-Jian Wang, Chen, F.Y.*, Characterization of a new peritrophin homolog from Scylla paramamosain and its role in molting and immune defense, Aquaculture, 594 (2025) 741457

He, W.Y., Zhang, C., Lan, H.J., Wu, G.P., Xiong, M., Peng, H., Chen, M.*, Ke-Jian Wang*, The topical application of Sphistin12-38 in combination with sponge spicules for the acne treatment, Drug Delivery and Translational Research, 2024.

Meng, X.Z., Duan, Y.Y., Bai, Y.Q., Zhang, W.B., Zhang, C., Chen, F.Y.*, Ke-Jian Wang*, The antimicrobial peptide Sparamosin26–54 exhibits antiviral activity against three aquatic enveloped viruses through lipid-binding-mediated virus lysis, Aquaculture, 592(2024)741160

Sun, H., Chen, F.Y., H., Hao, Xiong, M., Peng, H.,An, Z., Ke-Jian Wang*, Benefcial efects of AMP Scy-hepc on the gut microbiota contribute to the potential growth of Larimichthys crocea, Blue Biotechnology, (2024) 1:11

Sun, H., Chen, F.Y., Zhang, W.B., Huang, Y.X., Peng, H., Hao, H., Ke-Jian Wang*, Impact of captivity and natural habitats on gut microbiome in Epinephelus akaara across seasons, BMC Microbiology, (2024)24:239

Sun, H., Wang, L.X., Chen, F.Y., Meng, X.Y., Zhang, W.B., Peng, H., Hao, H.,Chen, H.Y., Ke-Jian Wang*, The modulation of intestinal commensal bacteria possibly contributes to the growth and immunity promotion in Epinephelus akaara after feeding the antimicrobial peptide Scy-hepc, Animal Microbiome, (2024) 6:54

Zeb, R., Yin, X.H., Chen, F.Y., Ke-Jian Wang*, Chronic exposure to environmental concentrations of benzo[a]pyrene causes multifaceted toxic effects of developmental compromise, redox imbalance, and modulated transcriptional profiles in the early life stages of marine medaka (Oryzias melastigma ), Aquatic Toxicology, 273(2024)107016

Zhang, C., Chen, F.Y.*, Bai, Y.Q., Dong, X.X., Meng, X.Z., Ke-Jian Wang*, A novel antimicrobial peptide Spasin141-165 identified from Scylla paramamosain exhibiting protection against Aeromonas hydrophila infection, Aquaculture, 591(2024)741137

An, Z., Chen, F.Y., Hao, H., Xiong, M., Peng, H., Sun, H., Wang, K.J.* , Growth- promoting effect of antimicrobial peptide Scy-hepc on mariculture large yellow croaker Larimichthys crocea and the underlying mechanism, Fish & Shellfish Immunology, 2023,108649.

Chen,Y.C., Qiu, W.L., Zhang, W.B., Zhang, J.R., Chen, R.S., Chen, F.Y. *, Wang, K.J.* , A Novel Antimicrobial Peptide Sp-LECin with Broad-Spectrum Antimicrobial Activity and Anti-Pseudomonas aeruginosa Infection in Zebrafish，International Journal of Molecular Sciences, 2023, 24, 267.

Li, S., Li, W.,F., Chen, F.Y., Zhu, X.,W., Chen., H.Y., Hao, H., Wang, K.J.* , Metabolomic and transcriptomic analysis reveals immune and hormone modulation at the molting stage of juvenile mud crabs challenged with Staphylococcus aureus and Vibrio alginolyticus，Aquaculture, 575 (2023) 739775.

Long, S., Chen, F.Y., Li, J.S., Yang,Y., Wang, K.J.* , A New Gene SCY3 Homologous to Scygonadin Showing Antibacterial Activity and a Potential Role in the Sperm Acrosome Reaction of Scylla paramamosain，International Journal of Molecular Sciences, 2023,24, 5689.

Meng, X.Y., Chen, F.Y., Xiong, M., Hao, H., Wang, K.J.*, A new pathogenic isolate of Kocuria kristinae identified for the first time in the marine fish Larimichthys crocea, Frontiers in Microbiology, 2023.1129568

Zhang, W.B., An, Z., Bai, Y.Q., Zhou, Y., Chen, F.Y. *, Wang, K.J.* , A novel antimicrobial peptide Scyreptin1-30 from Scylla paramamosain exhibiting potential therapy of Pseudomonas aeruginosa early infection in a mouse burn wound model, Biochemical Pharmacology, 218 (2023) 115917.

Zhou, Y., Meng, X.Y., Chen, F.Y., Xiong, M., Zhang, W.B., Ke-Jian Wang* , Newly discovered antimicrobial peptide Scyampcin44-63 from Scylla paramamosain exhibits a multitargeted candidacidal mechanism in vitro and is effective in a murine model of vaginal candidiasis, Antimicrobial Agents and Chemotherapy, 2023

Chen, J.C., Fang, C., Zheng, R.H., Chen M.L., Kim, D.H., Lee, Y.H., Bailey, C., Wang, K.J. , Lee, J.S., Bo, J.*, Environmentally relevant concentrations of microplastics modulated the immune response and swimming activity, and impaired the development of marine medaka Oryzias melastigma larvae, Ecotoxicology and Environmental Safety, 2022.113843

Dong, M., Wang, W.L., Wang, L.L., Liu, Y., Ma., Y.W., Li, M. j., Liu, H.P., Wang, K.J. , Song, L.S.*, The characterization of an agranulocyte-specific marker (CgCD9) in the Pacific oyster Crassostrea gigas, Fish and Shellfish Immunology, 2022.06.067

Gong, R.H.#, An, Z.#, Zhang, W.B., Chen, F.Y., Wang, K.J.* , The Antimicrobial Peptide LJ‐hep2 from Lateolabrax japonicus Exerting Activities against Multiple Pathogenic Bacteria and Immune Protection In Vivo, Marine Drugs, 2022, 20, 651.

Jiang, M.Y., Chen R.S., Zhang, J.R., Chen, F.Y. *, Wang, K.J.* , A Novel Antimicrobial Peptide Spampcin56–86 from Scylla paramamosain Exerting Rapid Bactericidal and Anti-Biofilm Activity In Vitro and Anti-Infection In Vivo, International Journal of Molecular Sciences, 2022, 23,13316.

Jiang, M.Y., Chen, R.S., Chen, F.Y.*, Zhu, X.W., Wang K.J. , A New Crustin Gene Homolog SpCrus8 Identified in Scylla paramamosain Exerting In Vivo Protection Through Opsonization and Immunomodulation, Frontiers in Immunology, 2022, 13: 946227.

Li, J.S., Qiu, W.L., Hao, H., Chen, F.Y., Wang K.J.*, Morphology of the complete embryonic and larval development of commercially important mud crab Scylla paramamosain , Aquaculture Research, 2022, 53: 2298–2316.

Li, W.F., Li, S., Liu, J., Wang, X.F., Chen, H.Y., Hao, H. and Wang K.J.*, Internal carbohydrates and lipids as reserved energy supply in the pubertal molt of Scylla paramamosain, Aquaculture, 2022, 23, 15.

Long, S., Chen, F.Y., Wang K.J.*, Characterization of two new Scygonadin homologous SCY4 and SCY5 in Scylla Paramamosain, Aquaculture, 559 (2022) 738428.

Sun, H., Chen,F.Y., Hao, H., Wang, K.J.* , Multi-dimensional investigation and distribution characteristics analysis of gut microbiota of different marine fish in Fujian Province of China, Frontiers in Microbiology ,2022.918191.

Wang, X. F., Hong, X., Chen, F.Y., Wang, K.J. *, A truncated peptide Spgillcin177–189 derived from mud crab Scylla paramamosain exerting multiple antibacterial activities, Frontiers in Cellular and Infection Microbiology, 2022, 8, 928220.

Yang Y., Chen H.Y., Hao H., Wang K.J.*, The Anticancer Activity Conferred by the Mud Crab Antimicrobial Peptide Scyreprocin through Apoptosis and Membrane Disruption, Int. J. Mol. Sci., 2022,23,5500.

Yang, Y., Chen, F.Y., Qiao, K., Zhang, H., Chen, H.Y., Wang K.J.*, Two Male-Specific Antimicrobial Peptides SCY2 and Scyreprocin as Crucial Molecules Participated in the Sperm Acrosome Reaction of Mud Crab Scylla paramamosain, International Journal of Molecular Sciences, 2022, 23, 3373.

Zhu X.W., Chen, F.Y., Li, S., Peng H., Wang K.J.*, A Novel Antimicrobial Peptide Sparanegtin Identified in Scylla paramamosain Showing Antimicrobial Activity and Immunoprotective Role In Vitro and Vivo, International Journal of Molecular Sciences, 2022, 23, 15.

Chen, Y.C., Yang, Y., Zhang, C., Chen, H.Y., Chen, F. Y.* and Wang K.J.*, A Novel Antimicrobial Peptide Sparamosin26–54 From the Mud Crab Scylla paramamosain Showing Potent Antifungal Activity Against Cryptococcus neoformans, Frontiers in Microbiology, 2021, 12, 746006.

Li, W.F., Li, S., Liu, J., Wang, X.F., Chen, H.Y., Hao, H. and Wang K.J.*, Vital Carbohydrate and Lipid Metabolites in Serum Involved in Energy Metabolism during Pubertal Molt of Mud Crab (Scylla paramamosain), Metabolites, 2021, 11, 651.

Long, S., Chen, F.Y.*, Wang K.J., Characterization of a new homologous anti-lipopolysaccharide factor SpALF7 in mud crab Scylla paramamosain. Aquaculture, 534 (2021) 736333.

Zhang, H., Yang, Y., Zhu, X.W., Liu, Y.Z., Chen, F.Y.*, Wang K.J.*, A truncated peptide Sp-NPFin from the neuropeptide FII SpNPFII of Scylla paramamosain exhibiting potent antimicrobial activity, Aquaculture, 533 (2021) 736145.

Zhu, D.P., Chen, F.Y., Chen, Y.C., Peng, H. and Wang K.J.*, The Long-Term Effect of a Nine Amino-Acid Antimicrobial Peptide AS-hepc3(48-56) Against Pseudomonas aeruginosa With No Detectable Resistance, Frontiers in Cellular and Infection Microbiology, 2021, 11, 752637.

Gao, Y., Liu, L.K., Wang K.J., Liu, H.P.*, A negative elongation factor E inhibits white spot syndrome virus replication by suppressing promoter activity of the viral immediate early genes in red claw crayfish Cherax quadricarinatus, Developmental and Comparative Immunology, 107 (2020) 103665.

Li, J.S., Dong, L.X., Zhu, D.P., Zhang, M., Wang K.J., Chen, F.Y.*, An effector caspase Sp-caspase first identified in mud crab Scylla paramamosain exhibiting immune response and cell apoptosis. Fish and Shellfish Immunology, 2020, 103: 442-453.

Li, M.J., Dong, M.R., Wang, W.L., Li, H., Liu, Z.Q., Wang, L.L.,Wang K.J., Song, L.S.*, A membrane-bound dopamine β-hydroxylase highly expressed in granulocyte of Pacific oyster Crassostrea gigas, Developmental and Comparative Immunology, 104 (2020) 103563.

Liu, J., Chen, F.Y., Wang, X.F., Peng, H., Zhang, H.,Wang K.J.*, The Synergistic Effect of Mud Crab Antimicrobial Peptides Sphistin and Sph12−38 With Antibiotics Azithromycin and Rifampicin Enhances Bactericidal Activity Against Pseudomonas Aeruginosa, Frontiers in Cellular and Infection Microbiology, 2020, 10, 572849.

Liu, L.K., Chen, X.X., Gao, R.L., Wang K.J.., Zheng, W.Y., Liu, H.P.*, A cytokine receptor domeless promotes white spot syndrome virus infection via JAK/STAT signaling pathway in red claw crayfish Cherax quadricarinatus, Developmental and Comparative Immunology, 111 (2020) 103749.

Liu, L.K., Gao, R.L., Gao, Y., Xu, J.Y., Guo, L.M. Wang K.J., Liu, H.P.*, A histone K-lysine acetyltransferase CqKAT2A-like gene promotes white spot syndrome virus infection by enhancing histone H3 acetylation in red claw crayfish Cherax quadricarinatus. Developmental and Comparative Immunology, 107 (2020) 103640.

Liu, S., Pan, C.Y., Tang, Y., Chen, F.Y., Yang, M. *, Wang K.J., Identification of novel long non-coding RNAs involved in bisphenol A induced immunotoxicity in fish primary macrophages, Fish and Shellfish Immunology, 2020, 100: 152-160.

Qiu, W.H., Liu, S., Chen, H.H., Luo, S.S., Xiong, H., Xu, B.T.*, Zheng, C.M.*, Wang K.J., The comparative toxicities of BPA, BPB, BPS, BPF, and BPAF on the reproductive neuroendocrine system of zebrafish embryos and its mechanisms, Journal of Hazardous Materials, 406 (2021) 124303.

Yang, Y., Chen, F.Y., Chen, H.Y., Peng, H., Hao, H.,Wang K.J.*, A novel antimicrobial peptide scyreprocin from mud crab Scylla paramamosain showing potent antifungal and anti-biofilm activity, Frontiers in Microbiology, 2020, 11, 01589.

Yin, X.H., Liu, Y., Zeb, R., Chen, F.Y., Chen, H.Y., Wang K.J.*, The intergenerational toxic effects on offspring of medaka fish Oryzias melastigma from parental benzo[a]pyrene exposure via interference of the circadian rhythm, Environmental Pollution, 267 (2020) 115437.

Bo, J., Y Ying., Zheng R., Fang C., Jiang Y., Liu J., Chen M., Hong F., Bailey C., Segner H., Wang K.J.*, Antimicrobial activity and mechanisms of multiple antimicrobial peptides isolated from rockfish Sebastiscus marmoratus, Fish and Shellfish Immunology, 2019. 93: 1007-1017.

Chen, F.Y., Wang K.J.*, Characterization of the innate immunity in the mud crab Scylla paramamosain, Fish and Shellfish Immunology, 2019. 93: 436-448.

Cui, Q., Chen, F.Y., Chen, H.Y., Peng, H., Wang K.J.*, Benzo[a]pyrene (BaP) exposure generates persistent reactive oxygen species (ROS) to inhibit the NF-κB pathway in medaka (Oryzias melastigma)，Environmental Pollution, 2019, 251: 502-509.

Cui, Q., Chen, F.Y., Zhang, M., Peng, H., Wang K.J.*, Transcriptomic analysis revealing hepcidin expression in Oryzias melastigma regulated through the JAK-STAT signaling pathway upon exposure to BaP, Aquatic Toxicology, 2019, 206: 134-141.

Li, M.J., Wang, M., Wang, W.L., Wang L.L., Liu, Z.Q., Sun J.J., Wang K.J.*, Song, L.S.∗, The immunomodulatory function of invertebrate specific neuropeptide FMRFamide in oyster Crassostrea gigas, Fish and Shellfish Immunology, 2019. 88: 480-488.

Qiu, W.H.*, Fang M, Liu J, Fu C, Zheng C, Chen B, Wang K.J.*, In vivo actions of Bisphenol F on the reproductive neuroendocrine system after long-term exposure in zebrafish, Science of the Total Environment, 2019, 665: 995-1002.

He, Y.B., Peng, H., Liu, J., Chen, F.Y., Zhou, Y., Ma, X.W., Chen, H.Y., Wang K.J.*, Chlorella sp. transgenic with Scy-hepc enhancing the survival of Sparus macrocephalus and hybrid grouper challenged with Aeromonas hydrophila, Fish and Shellfish Immunology, 2018, 73, 22-29.

Qiu W., Yang M*, Liu S., Lei, P., Hu, Lei., Chen B.,Wu M., Wang K.J.*, Toxic Effects of Bisphenol S Showing Immunomodulation in Fish Macrophages, Environmental Science & Technology, 2018. 52(2): 831-838.

Zhang, M., Zhang, M.F., Chen,F.Y., Cui, Q., Yang, B.Z., Y. Liu, H. Peng, Wang K.J.*, The transcriptional regulation of an antimicrobial peptide hepcidin1 in Oryzias melastigma upon EE2 exposure involved in a new pathway with a novel transcriptional regulatory element HepERE, Fish and Shellfish Immunology, 2018. 82: 421-431.

Li, Y.H., Zhuang, S.F., Wu, Y.P., Ren, H.L., Chen, F.Y., Lin, X., Wang K.J.*, John B., Gao, K.S.*, Ocean acidification modulates expression of genes and physiological performance of a marine diatom, PLOS ONE, 2017; 12(2): e0170970.

Ma X.W., Hou, L., Chen, B., Fan, D.Q., Chen, Y.C., Yang, Y., Wang K.J.*, A truncated Sph12-38 with potent antimicrobial activity showing resistance against bacterial challenge in Oryzias melastigma, Fish and Shellfish Immunology, 2017, 67: 561-570.

Qiu, W.H., W M., Liu S., Chen B, Pan C., Yang M*, Wang K.J.*, Suppressive immunoregulatory effects of three antidepressants via inhibition of the nuclear factor-κB activation assessed using primary macrophages of carp (Cyprinus carpio), Toxicology and Applied Pharmacology, 2017, 322, 1-8.

Qiao, K., Xu, W.F., Chen, H.Y., Peng, H., Zhang, Y.Q., Huang, W.S., Wang, S.P., An, Z., Shan, Z.G., Chen, F.Y., Wang K.J.*, A new antimicrobial peptide SCY2 identified in Scylla Paramamosain exerting a potential role of reproductive immunity, Fish and Shellfish Immunology, 2016,51,251-262.

Qiu W., Shen Y., Pan C., Liu S., Wu M., Yang M.*, Wang K.J.*, The potential immune modulatory effect of chronicbisphenol A exposure on gene regulation in male medaka (Oryzias latipes) liver, Ecotoxicology and Environmental Safety, 2016,130, 146-154.

Shan, Z. G., Zhu, K. X., Chen, F. Yi., Liu, J., Chen, B., Qiao, K., Peng, H., Wang K.J.*, In vivo activity and the transcriptional regulatory mechanism of the antimicrobial peptide SpHyastatin in Scylla paramamosain, Fish and Shellfish Immunology, 2016, 59:155-165.

Shan, Z., Peng, H., Zhu, K., Chen, B., Liu, J., Chen F., Ma, X., Wang, S., Kun, Q., Wang K.J.*, The New Antimicrobial Peptide SpHyastatin from Mud Crab Scylla paramamosain with Multiple Antimicrobial Mechanisms and High Effect on Bacterial Infection, Frontiers in Microbiology, 2016, 7:1140.

Chen, B., Fan, DQ., Zhu, KX., Shan, ZG., Chen, FY., Hou, L., Cai, L.，Wang K.J.*, Mechanism study on a new antimicrobial peptide Sphistin derived from the N-terminus of crab histone H2A identified in haemolymphs of Scylla paramamosain, Fish and Shellfish Immunology, 2015, 47, 833-846.

Chen, F.Y., Bo, J., Ma, X.W., Dong, L.X., Shan, Z.G., Cui, Q., Chen, H.Y., Wang K.J.*, A New Membrane Lipid Raft Gene SpFLT-1 Facilitating the Endocytosis of Vibrio alginolyticus in the Crab Scylla paramamosain. PLOS ONE, 2015, 10 (7): e0133443.

Ding, J., Peng, H., Cui, Q., Wang K.J.*, Molecular cloning and characterization of a novel pathogen-induced trypsin-like protease in Scylla paramamosain (Estampador 1949) [J]. Aquaculture Research, 2015, 46(3): 759-764.

Wang, SP., Chen, FY., Dong, LX., Zhang, YQ., Chen, HY., Qiao, K.,Wang K.J.*, A novel innexin2 forming membrane hemichannel exhibits immune responses and cell apoptosis in Scylla paramamosain, Fish and Shellfish Immunology, 2015, 47, 485-499.

Yang, M.*, Qiu, W., Chen, B., Chen, J., Liu, S., Wu, M., Wang K.J.*, The in vitro immune modulatory effect of bisphenol A on fish macrophages via estrogen receptor α and nuclear factor-κB signaling,Environmental Science & Technology, 2015,49 (3), 1888-1895.

Bo, J., Gopalakrishnan, S., Chen, F.Y., Wang K.J.*, Benzo[a]pyrene modulates the biotransformation, DNA damage and cortisol level of red sea bream challenged with lipopolysaccharide. Marine Pollution Bulletin. 2014,85:463-470.

Thilagam, H., Gopalakrishnan, S., Bo, J., Wang K.J.*, Comparative study of 17 β-estradiol on endocrine disruption and biotransformation in fingerlings and juveniles of Japanese sea bass Lateolabrax japonicus, Marine Pollution Bulletin, 2014, 85: 332-337.

Zhang, YQ., Qiao, K., Wang, SP., Peng, H., Shan, ZG., Wang K.J.*, Molecular identification of a new androgenic gland-specific insulin-like gene from the mud crab, Scylla paramamosain. Aquaculture, 2014, 433:325-334.

Ding, J., Chen, F.Y., Ren, S.Y., Qiao, K., Chen, B., Wang K.J.*, Molecular characterization and promoter analysis of crustacean heat shock protein 10 in Scylla paramemosain, Genome: 2013, 56 (5): 272-81.

Jiang, J.L., Wang, G.Z., Mao, M.G.,Wang K.J., Differential gene expression profile of the calanoid copepod, Pseudodiaptomus annandalei, in response to nickel exposure, Comparative Biochemistry and Physiology, Part C, 2013, 157: 2: 203-211.

Mao, M.G.; Jiang, J.L.; Peralvarez-Marin, A; Wang K.J.; Lei, J.L., Characterization of the Mx and hepcidin genes in Epinephelus akaara asymptomatic carriers of the nervous necrosis virus, Aquaculture, 2013, 408:175-183.

Qu, H.D., Chen, B., Peng, Hui., Wang K.J.*, Molecular Cloning, Recombinant Expression and Antimicrobial Activity of EC-hepcidin3, a New Four-cysteine Hepcidin Isoform from Epinephelus coioides, Bioscience, Biotechnology, and Biochemistry, 2013, 77(1):103-110.

Bo J, Gopalakrishnan S, Fan DQ, Thilagam H, Qu HD, Zhang N, Chen FY,Wang K.J.*, Benzo[a]pyrene modulation of acute immunologic responses in red sea bream pretreated with lipopolysaccharide. Environmental Toxicology, 2012, 29(5):517-525.

Cai, L., Cai, J. J., Liu, H. P., Fan, D. Q., Peng, H., Wang K.J.*, Recombinant medaka (Oryzias melastigma) pro-hepcidin: Multifunctional characterization, Comparative Biochemistry and Physiology, Part B, 2012,161, 140–147.

Mao, M.G., Lei, J.L., Alex, P.M., Hong, W.S., Wang K.J.*, Characterization of RAG1 and IgM (mu chain) marking development of the immune system in red-spotted grouper (Epinephelus akaara), Fish and Shellfish Immunology, 2012, 33:725-735.

Peng, H., Liu, H.P., Chen, B., Hao, H., Wang K.J.*, Optimized production of scygonadin in Pichia pastoris and analysis of its antimicrobial and antiviral activities, Protein Expression and Purification, 2012, 82, 37-44.

王克坚，海洋鱼类和青蟹抗菌肽hepcidin和scygonadin的研究，厦门大学学报（自然科学版），2011年3月，第50卷，第2期。

Bo, J., Cai L., Xu J.H, Wang K.J.*, Au, D.*, The marine medaka Oryzias melastigma - a potential marine fish model for innate immune study, Marine Pollution Bulletin, 2011, 63, 267-276.

Gopalakrishnan, S., Chen, F.Y., Thilagam, H., Qiao, K., Xu, W.F., Wang K.J.*, Modulation and interaction of immune-associated parameters with antioxidant in the immunocytes of crab Scylla paramamosain challenged with lipopolysaccharides, Evidence-Based Complementary and Alternative Medicine, 2011, 824962: 1-8.

Gopalakrishnan, S., Huang, W. B., Wang, Q.W., Wu, M. L., Liu, J., Wang K.J.*, Effects of tributyltin and benzo[a]pyrene on the immune-associated activities of hemocytes and recovery responses in the gastropod abalone, Haliotis diversicolor, Comparative Biochemistry and Physiology, Part C, 2011, 154, 120-128.

Gopalakrishnan, S., Zhang, N., Thilagam, H., Chen, B., Ding, J., Wang, X.H., Wang, W. X., Ke, C. H., Giesy, J. P., Zhang, X., Wang K.J.*, Biochemical responses and DNA damage in red sea bream from coastal Fujian Province, China, Ecotoxicology and Environmental Safety, 2011, 74, 1526-1535.

Liu, H.P. *, Chen, R.Y., Zhang, Q.X., Peng, H., Wang K.J., Differential gene expression profile from haematopoietic tissue stem cells of red claw crayfish, Cherax quadricarinatus, in response to WSSV infection, Developmental & Comparative Immunology, 2011, 35, 716-724.

Xu, W.F., Qiao, K., Huang, S.P., Huang, S. P., Peng, H., Huang, W.S., Chen, F.Y., Bo, J., Wang K.J.*, Quantitative gene expression and in situ localization of Scygonadin potentially associated with reproductive immunity in tissues of male and female mud crabs, Scylla paramamosain, Fish and Shellfish Immunology, 2011, 31, 243-251.

Xu, W.F., Qiao, K., Huang, S.P., Peng, H., Huang, W.S., Chen, F.Y., Zhang, N., Wang, G.Z., Wang K.J.*, The expression pattern of scygonadin during the ontogenesis of Scylla paramamosain predicting its potential role in reproductive immunity, Developmental & Comparative Immunology, 2011, 35, 1076-1088.

Yang, M., Chen, B., Cai, J.J., Peng, H., Cai, L., Yuan, J.J., Wang K.J.*, Molecular characterization of hepcidin AS-hepc2 and AS-hepc6 in black porgy (Acanthopagrus schlegelii):Expression pattern responded to bacterial challenge and in vitro antimicrobial activity. Comparative Biochemistry and Physiology, Part B, 2011; 158:155-163.

Chen, F.Y., Liu, H.P., Bo, J., Ren, H.L., Wang K.J.*, Identification of genes differentially expressed in hemocytes of Scylla paramamosain in response to lipopolysaccharide, Fish and Shellfish Immunology, 2010, 28, 167-177.

He, B., Dai, M *, Zhai, W., Wang, L., Wang K.J., Chen, J., Lin, J., Han, A., and Xu, Y., Distribution, degradation and dynamics of dissolved organic carbon and its major compound classes in the Pearl River estuary, China, Marine Chemistry, 2010, 119, 52-64.

Huang, W.B., Ren, H.L., Gopalakrishnan, S., Xu, D.D., Qiao, K., Wang K.J.*, First molecular cloning of a molluscan caspase from variously colored abalone (Haliotis diversicolor) and gene expression analysis with bacterial challenge, Fish and Shellfish Immunology, 2010, 28, 587-595.

Liu, H.P., Chen, F.Y., Gopalakrishnan, S., Qiao, K., Bo, J.,Wang K.J.*, Antioxidant enzymes from the crab Scylla paramamosain: gene cloning and gene/protein expression profiles against LPS challenge, Fish and Shellfish Immunology, 2010, 28, 862-871.

Liu, H.P., Chen, R.Y., Zhang, M., Wang K.J., Isolation, gene cloning and expression profile of a pathogen recognition protein: a serine proteinase homolog (Sp-SPH) involved in the antibacterial response in the crab Scylla paramamosain, Developmental & Comparative Immunology, 2010, 34, 741-748.

Onsanit, S., Ke, C., Wang, X., Wang K.J., Wang, W.X *，Trace elements in two marine fish cultured in fish cages in Fujian province, China，Environmental Pollution，2010, 158(5), 1334-1342.

Peng, H., Yang, M., Huang, W. S., Ding, J., Qu, H.D., Cai, J.J., Zhang, N., Wang K.J.*, Soluble expression and purification of a crab antimicrobial peptide scygonadin in different expression plasmids and analysis of its antimicrobial activity，Protein Expression and Purification, 2010, 70, 109-115.

Thilagam, H., Gopalakrishnan, S., Qu, H.D., Bo, J., Wang K.J.*, 17 β-estradiol induced ROS generation, DNA damage and enzymatic responses in the hepatic tissue of Japanese seabass, Ecotoxicology, 2010,19:1258-1267.

Wang K.J.*, Bo, J., Yang, M., Hong, H.S., Wang, X.H., Chen, F.Y., Yuan, J.J., Hepcidin gene expression induced in the developmental stages of fish upon exposure to Benzo[a]pyrene (BaP), Marine Environmental Research, 2009, 69: 159-165.

Wang K.J.*, Cai, J.J., Cai, L., Qu, H.D.,Yang, M., Zhang, M., Cloning and expression of a hepcidin gene from a marine fish (Pseudosciaena crocea) and the antimicrobial activity of its synthetic peptide. Peptides, 2009, 30: 638-646.

Gopalakrishnan, S., Thilagam, H., Huang,W.B., Wang K.J.*, Immunomodulation in the marine gastropod Haliotis diversicolor exposed to Benzo(a)pyrene. Chemosphere, 2009, 75: 389-397.

Ren, H.L., Xu, D.D., Gopalakrishnan, S., Qiao, K., Huang, W.B., Wang K.J.*, Gene cloning of a sigma class glutathione S-transferase from abalone (Haliotis diversicolor) and expression analysis upon bacterial challenge, Developmental & Comparative Immunology, 2009, 33, 980-990.

Thilagam, H., Gopalakrishnan, S., Bo, J., Wang K.J.*, Effect of 17beta-estradiol on the immunocompetence of Japanese sea bass (Lateolabrax japonicus), Environmental Toxicology and Chemistry, 2009, 28 (8): 1722-1731.

Xu, X.J., Wang, G.Z., Wang K.J., Li, S.J. Isolation and characterization of ten new polymorphic microsatellite loci in the mud crab, Scylla paramamosain, Conserv Genet, 2009, 10: 1877-1878.

任洪林，柳增善，王克坚*，鲍免疫相关基因和蛋白的研究进展，遗传（综述），2009年4月, 31(4): 348-358。

Wang K.J.*, Ren, H.L., Xu, D.D., Cai, L., Yang, M., Identification of the up-regulated expression genes in hemocytes of Variously Colored Abalone (Haliotis diversicolor Reeve, 1846) challenged with bacteria, Developmental & Comparative Immunology, 2008, 32: 1326-1347.

任洪林, 徐丹丹, 乔琨, 蔡灵, 黄伟滨, 张鼐, 王克坚*，细菌攻毒杂色鲍血淋巴细胞抑制性差减杂交文库构建及巨噬细胞表达蛋白 cDNA 的克隆与差异表达，遗传（研究报告），2008 年 8 月, 30(8): 1043-1050。

Wang K.J.*, Huang, W.S., Yang, M., Chen, H.Y., Bo, J., Li, S. J., Wang G.Z., A male-specific expression gene, encodes a novel anionic antimicrobial peptide, scygonadin, in Scylla serrata. Molecular Immunology, 2007, 44: 1961-1968.

Wang, G.Z.*, Kong, X.H., Wang K.J., Li, S.J., Variation of specific proteins, mitochondria and fatty acid composition in gill of Scylla serrata (Crustacea, Decapoda) under low temperature adaptation, Journal of Experimental Marine Biology and Ecology, 2007, 352:1326-1347.

Yang, M., Wang K.J.*, Chen, J.H., Qu, H.D., Li, S. J., Genomic organisation and tissue-specific expression analysis of Hepcidin-like genes from black porgy (Acanthopagrus schlegelii B.), Fish and Shellfish Immunology, 2007, 23:1060-1071.

黄文树，李少菁，蔡灵，杨明，陈君慧，王克坚∗，尼罗罗非鱼Hepcidin基因结构与序列分析，厦门大学学报（自然科学版），2007年5月，第46卷，第3期。

Huang, W.S.,Wang K.J.*, Yang, M., Cai J.J., Li S. J., Wang, G.Z., Purification and part characterization of a novel antibacterial protein Scygonadin, isolated from the seminal plasma of mud crab, Scylla serrata ((Forkal , 1775), Journal of Experimental Marine Biology and Ecology, 2006, 399:37-42.

Ren, H.L., Wang K.J.*, Zhou, H.L., Yang, M., Cloning and organization analysis of a hepcidin-like gene and cDNA from Japan sea bass, Lateolabrax japonicus, Fish and Shellfish Immunology, 2006,21: 221-227.

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