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Marine pollution, ecotoxicology and sustainability
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Two-generation Toxicological Study of Triphenyl Phosphate (TPhP)in Marine Medaka (Oryzias melastigma)
P-E1-18-S
Daiyin Zhong* , Xiamen university
Haizheng Hong, Xiamen university
Presenter Email: zhongdy@stu.xmu.edu.cn |
| Triphenyl phosphate (TPhP), a commonly used additive organic phosphate flame retardant in a wide range of materials, has become a ubiquitous contaminant in the environmental media and biota, including the marine environment and organisms. Since TPhP has been detected in marine fish at a relatively high concentration, its potential adverse effect on marine organisms is of great concern. In order to understand the chronic toxicity of TPhP to the development of marine medaka, two-generations exposure experiment, as long as 10 months, was conducted in the laboratory. Results showed that TPhP exposure caused severe lethality to marine medaka, especially during the embryo phase, even at the lowest exposure concentration (i.e. 5 ug L-1). In all the exposure groups (5, 10, 50 ug/L), TPhP significantly decreased the embryo heart beats. The malformation rates at the 1st fry and adult fish were also induced by TPhP at a dose dependent manner, with the formation of bent pectoral fin and pericardial and yolk sac edema, and spinal curvature as the most frequently observed malformation in the adult fish. In the adults it was found that TPhP exposure affected the sex ratio obviously and the ratio of Female/Male significantly increased with the increasing doses. Consistently, gonadosomatic index (GSI) in the male adult fish decreased, suggesting the estrogenic effects of TPhP. In addition, hepatosomatic index (HSI) showed negative correlation with the concentrations of TPhP. These results suggested that TPhP exposure markedly affected skeletal/cartilaginous, cardiovascular and liver development, and caused estrogenic effects in marine medaka. The present study provides a set of systematic toxicity data of TPhP on marine medaka and could be of great help for the assessment of the potential risk of TPhP to the marine ecosystems. |
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