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General Session 4: Marine environment, ecosystem & sustainability |
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Developmental toxicity and embryotoxicity of sulfamethazine in marine medaka (Oryzias melastigma) embryos
GS4-37
Xinhong Wang* , State Key Laboratory of Marine Environmental Science, Xiamen University
Gengli Wang, College of the Environment and Ecology, Xiamen University
Songhe Zhao, Coollege of the Environment and Ecology, Xiamen University
Presenter Email: xhwang@xmu.edu.cn
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| Sulfamethazine (SMZ) is not only extensively used in treatment of human diseases, but also largely used as the long-term additive in animal feed, and now is a kind of ubiquitous contaminants in the environmental media and biota. Bioaccumulation and potential developmental toxicity of SMZ in marine medaka (Oryzias melastigma) embryos were studied. Results indicated that bioaccumulation of SMZ in embryos showed a significant dose-response relationship. The main embryos¡¯ malformation was hemoglutination, and, the region and manifestation of hemoglutination were irregular. Yolk sac edema was the main malformation at the larvae stage. The mortality and malformation rates of embryos and hatched larvae were induced by SMZ in a concentration-dependent manner. And the trend of embryonic mortality was so similar to the trend of hemoglutination rate that the hemoglutination was probably the main cause of embryonic death. The embryonic heart beats increased with increasing SMZ concentrations on 4 dpf and 12dpf, implied a certain toxic effect on development of embryonic heart tissue. Suffering from exposure to SMZ, superoxide dismutase (SOD) and catalase (CAT) activities of embryos showed a significant dose-effect relationship, and SMZ could induce oxidative stress of embryos. When the SMZ bioaccumulation in embryos reached 10 ng/embryo, SOD activity be significantly inhibited, and caused oxidative lesions on O. melastigma embryos. The results indicated that fish at the early development stage was sensitive to antibiotic and need to rational administration in fries aquaculture.
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